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Investigación

09
Feb
2023
The image shows pancreatic islets in mice, specialised tissues that host beta cells. On the left, a healthy pancreatic islet is shown with its typical morphology with alpha cells in the periphery and beta cells in the core of the islet. On the right, mice with a mutation in Srrm3 that knock out the cells’ ability to regulate microexon inclusion results in islets with altered morphology and cell identity. This and other functional alterations ultimately impacts on the release of insulin. Jonas Juan Mateu
‘Tiny but mighty’ gene fragments are crucial for maintaining blood sugar levels

Microexons constitute new potential therapeutic targets for treating diabetes

INVESTIGACIóN
19
Ene
2023
This shows a cross-section of a mouse lung infected with Pseudonomas aeruginosa. The mouse was treated with a version of Mycoplasma pneumoniae that could not produce therapeutic molecules, resulting in severe pneumoniae. This is characterised by massive infiltration of inflammatory cells into the alveolar septa, resulting in loss of air in the alveoli. Credit: Rocco Mazzolini/CRG
‘Living medicine’ created to tackle drug-resistant lung infections

Study showcases synthetic biology's potential in transforming treatment of human disease

INVESTIGACIóN
28
Dic
2022
Human diabetes risk influenced by genomic regulation of RNA splicing

RNA splicing regulation influences transcription of genes inked to type-1 and type-1 diabetes risk

INVESTIGACIóN
28
Nov
2022
Image 1. Mitotic spindles with microtubules (red) attached to chromosomes (blue) during cell division. Cells with normal TTLL11 function (right) have normal rates of microtubule polyglutamylation (green) while cells without TTLL11 (left) are unmodified. Isabelle Vernos
Cell division enzyme earmarked as potential new cancer therapeutic target

The enzyme’s activity was found to be compromised in human cancer cells

INVESTIGACIóN
27
Oct
2022
Image of a mouse pancreatic islet, regions in the pancreas that contain beta cells which secret insulin. The HASTER regulatory element has been knocked out in this mouse, resulting in changes to beta cell function that cause diabetes. Credit: Miguel A Garriga/
Diabetes-causing gene can be regulated like a rheostat

Studying noncoding RNAs opens new avenues to understand human disease 

INVESTIGACIóN
19
Oct
2022
Alterations to gut mucous may trigger ulcerative colitis

The findings pave the way for the development of routine medical tests that predict the onset of the disease before symptoms appear

INVESTIGACIóN
13
Oct
2022
MiOS captures how genes fold and work at unprecedented resolution

New genome imaging technique is “like upgrading from the Hubble to the James Webb” 

INVESTIGACIóN
29
Sep
2022
Biomarkers used to track benefits of anti-ageing therapies can be misleading

Dr. Nick Stroustrup's 'Lifespan Machine' questions the use of ageing biomarkers

INVESTIGACIóN
22
Ago
2022
Researchers show how mutations in ‘dark genome’ cause pancreatic malformations

Researchers solve paradox of how mutations in a single enhancer can be catastrophic

INVESTIGACIóN
12
Ago
2022
Inflammation protein found to have new role in embryonic development

IL-6 has been linked to diseases such as rheumatoid arthritis and severe COVID-19.

INVESTIGACIóN

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Contact:

Omar Jamshed

Senior Press & Communications Officer
Phone +34 93 316 02 37