Beekman Lab

Beekman LabBeekman Lab

Genome Biology

Beekman Lab
Single Cell Epigenomics and Cancer Development
Group leader

Beekman Lab

Single Cell Epigenomics and Cancer Development
Group leader
We are offering a fully-funded PhD position in our lab

July 2023: Group Leader, Centre for Genomic Regulation (CRG, Barcelona, Spain) in double affiliation with the Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
January 2020-June 2023: Group Leader, Centre for Genomic Regulation and Centre for Genomic Analysis (CRG and CNAG-CRG, Barcelona, Spain) in double affiliation with the Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
2020-2021: La Caixa Junior Leader Fellow, Centre for Genomic Regulation and Centre for Genomic Analysis (CRG and CNAG-CRG, Barcelona, Spain) in double affiliation with the Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
2018-2019: La Caixa Junior Leader Fellow, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
2016-2018: Postdoctoral Fellow, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
2014-2016: Marie Curie Postdoctoral Fellow, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
2013-2014: Rubicon Postdoctoral Fellow, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS, Barcelona, Spain)
2008-2013: PhD in Medicine, Erasmus University (Rotterdam, The Netherlands)
2000-2007: Medical Degree, Erasmus University (Rotterdam, The Netherlands)
2001-2005: MSc in Molecular Medicine, Erasmus University (Rotterdam, The Netherlands)

News

 

Each Cancer Has Its Origin Story. Just Ask a Cell’s ‘Diary’ (25/01/2024)
DNA methylation acts like a cell’s personal diary. Reading this information at scale can unlock the next generation of advanced therapies for diseases like cancer. So why haven’t we unlocked this gold mine of information yet?

Researchers at the CRG receive €4.5m to study cancer, reproduction and blood formation (10/01/2022)
Renée Beekman will study the impact of translocations, a phenomenon where a chromosome breaks and a portion of it reattaches to a different chromosome, on the formation of tumours. Dr. Beekman’s group will study this in Non-Hodgkin lymphoma to identify potential new vulnerabilities in the disease.

Summary

How do malignant cells arise in healthy individuals? Our group aims to shed light upon this question by creating a better understanding of early epigenetic events that contribute to tumorigenesis.

Every tumor originates from a normal cell that, at a given moment, acquires tumor-initiating genetic events, such as translocations and somatic mutations affecting key proto-oncogenes or tumor suppressor genes. These genetic hits turn normal cells into pre-malignant cells, but do not lead to immediate tumor formation. For that, secondary genetic events as well as epigenetic hits, also known as epimutations, are required. In our group we aim to create a better understanding of how epimutations arise and how they contribute to tumorigenesis. We will do this in the context of non-Hodgkin lymphomas, such as mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma and Burkitt lymphoma.

Fuelled by the advent of single-cell technologies, it is becoming increasingly clear that individual cells in seemingly homogeneous cell populations show cell-to-cell variation in their genetic, epigenetic and gene expression landscapes. We aim to study the heterogeneity of oncogenic events in healthy individuals as well as in pre-malignant cells in vitro (to be created by CRISPR/Cas9 genomic editing) and in vivo using cutting-edge single-cell technologies. On top of that, we aim to define cell intrinsic mechanisms, such as enhancer activation and 3D chromatin interactions, that influence the observed heterogeneity. Altogether, we aim to create new insights into the source of epimutations with the ultimate goal to create a better understanding of the complex process of tumor formation.

Our group is physically located at the Barcelona Biomedical Research Park (PRBB building, C/ Dr. Aiguader, 88, Barcelona, Spain). We are affiliated to the Genome Biology research program (CRG, Barcelona, Spain), and the department of Oncology and Haematology (IDIBAPS, Barcelona, Spain). Together, these provide a unique niche covering basic, translational and clinical biomedical research, and single-cell sequencing technologies. We strongly believe that bringing the knowledge and resources of these different environments together majorly aids to better understand the biology of disease.

 

Funding Acknowledgements

            
The project R+D+I project "Plataforma de secuenciación de ADN de lecturas cortas de alto rendimiento y alta flexibilidad" (EQC2021-006925-P) is funded by the Spanish Ministry of Science and Innovation (MICIN), the State Research Agency (AEI) and the "European Union NextGenerationEU/PRTR".