Short CV

From July 2024 – Group Leader, Chromatin Folding and Nanoscopy Lab, Molecular Biology Institute of Barcelona (IBMB), Barcelona (Spain)
From July 2024 – Senior Visiting Scientist, Reprogramming and Regeneration Lab, Centre for Genomic Regulation (CRG), Barcelona (Spain)
2020 – 2024 Staff Scientist, Reprogramming and Regeneration Lab, Centre for Genomic Regulation (CRG), Barcelona (Spain)
2015 – 2020 Postdoctoral fellow, Reprogramming and Regeneration Lab, Centre for Genomic Regulation (CRG), Barcelona (Spain)
2015 – 2017 Visiting scientist, Institute of Photonic Sciences (ICFO), Castelldefels (Spain)
2013 – Ph.D in Cellular and Molecular Biology, San Raffaele University, Milan (Italy)

Web page of Dr. Victoria Neguembor at the IBMB, Barcelona, Spain

Summary

Within the nucleus of our cells, two meters of genetic material get folded in an organized manner to guarantee compaction and a proper pattern of gene expression. Understanding how this spectacular folding is achieved is key to unravel the bases of gene regulation in health and disease. However, the mechanisms controlling genome folding, in particular at the single gene level, are still largely unknown.

In this context, we focus on investigating how does gene folding and gene activity influence each other.

To address this question, we integrate advanced Super-resolution imaging strategies (STORM, Single Molecule Tracking, OligoSTORM, DNA-PAINT, PoSTAC) with quantitative analysis to resolve gene organization at the molecular level in single nuclei. Also, we develop ad hoc tools to label endogenous genomic regions allowing the study of gene dynamics at high temporal and spatial resolution.