ROPES

Emerging evidence indicates that like chromatin, mRNA carries certain covalent modifications. Although their role is still being investigated, it seems that these modifications determine the levels, translatability and subcellular compartmentalisation of target mRNAs with profound consequences for cell processes. The EU-funded ROPES project will focus on epitranscriptomics as the missing link between genomic variability and cellular phenotype. Results will help delineate disease mechanisms, identify novel biomarkers and develop innovative therapies. By training early-stage researchers, ROPES aims to establish a European framework that can accelerate research efforts and industrial applications in the promising field of epitranscriptomics.