This EMBO Workshop provides a unique forum bringing together scientists working at the forefront of liver and pancreatic endocrine biology and disease. It will discuss progress in our understanding of biological mechanisms underlying human metabolic diseases, as well as development of novel therapeutic strategies. It will span topics such as organ modeling, novel genomic technologies, gene regulation, human genetics, disease-relevant molecular and developmental processes, and genetic and cell replacement therapies. It has a highly multidisciplinary programme to promote collaborative and cross-fertilizing interactions. Each session will engage scientists working on both organs, with contributions from outside speakers from diverse academic and industry backgrounds. Numerous speakers will be selected from submitted abstracts.