PRBB-CRG Sessions Takashi Hiiragi

06/09/202412:00MARIE CURIEPRBB-CRG SessionsTakashi HiiragiHubrecht Institute"Optimality for developmental robustness"Host: Adel Al Jord & Verena RuprechtAbstract:Tissue patterning depends on the coordination between cellular dynamics, fate specification and tissue morphogenesis. Understanding how precision in patterning is robustly achieved despite the inherent developmental variability remains a challenge. Our group aims to understand the design principle of multi-cellular organisms using early mammalian embryos as a model system. Our studies showed that feedbacks between cell fate, polarity and cell/tissue mechanics underlie the robust formation of early mouse embryos. I will discuss our recent work that presents yet another mechanism that ensures robustness in development.