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2025 CRG Symposium ‘Mechanisms of Gene Expression: Unlocking Therapeutic Potential’

2025 CRG Symposium ‘Mechanisms of Gene Expression: Unlocking Therapeutic Potential’2025 CRG Symposium ‘Mechanisms of Gene Expression: Unlocking Therapeutic Potential’

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About

The 2025 CRG Symposium will illustrate how uncovering the fundamental mechanisms of gene expression has driven innovation and paved the way for novel disease treatments. The event will bring together leading researchers from diverse fields, including transcription, epigenetics, splicing, translation, metabolism, and protein folding, whose groundbreaking work has advanced progress towards therapeutic applications.

This year's CRG Symposium is organized by the Genome Biology Programme.

Program

Day 1 - 24th April 2025

08.45 Registration and welcome coffee
09.15 Opening remarks
09.30 "Targeting RNA modifying enzymes in the treatment of cancer"
Tony Kouzarides, Gurdon Institute and Milner Therapeutics Institute, University of Cambridge, UK
introduced by Luciano di Croce
10.30 "Oncohistones: Lessons in chromatin hijacking"
Nada Jabado, Research Institute of the McGill University Health Centre, CA
introduced by Marc Martí-Renom
11.30 Coffee Break
12.00 "LDB1 establishes multi-enhancer networks to drive gene transcription"
Gerd Blobel, Children's Hospital of Philadelphia, US
introduced by Renée Beekman
13.00 "Role of telomeres in disease"
María Blasco, Centro Nacional de Investigaciones Oncológicas, ES
introduced by Thomas Graf
14.00 Lunch
15.00 "Tumor cell plasticity in metastatic colorectal cancer"
Eduard Batlle, Institut de Recerca Biomèdica, ES
introduced by Fátima Gebauer
16.00 "Understanding and targeting spliceosomal gene mutations in leukemia"
Omar Abdel-Wahar, Memorial Sloan Kettering Cancer Center, US
introduced by Juan Valcárcel
17.00 Coffee Break
17.30 "Challenges and opportunities of attacking an “undruggable” target for cancer treatment"
Laura Soucek, Vall d'Hebron Institut d'Oncologia & Peptomyc, ES
introduced by Sara Sdelci
18.00 "Propagating Pluripotency"
Austin Smith, Living Systems Institute, University of Exeter, UK
introduced by Luciano di Croce

 

Day 2 - 25th April 2025

10.00 "Nutrition, cancer and RNA structure: a journey into new modes of gene regulation"
Davide Ruggero, UCSF Helen Diller Family Comprehensive Cancer Center, US
introduced by Fátima Gebauer
11.00 "Boosting cellular defense mechanisms as a treatment for degenerative diseases"
Anne Bertolotti, MRC Laboratory of Molecular Biology, UK
introduced by Markus Hoepfler
12.00 Coffee Break
12.30 "TBC"
Sònia Guedan, Institut d’Investigacions Biomèdiques August Pi i Sunyer, ES
introduced by Eva Novoa
13.00 "Leveraging single-cell technologies to engineer the immune system"
Ido Amit, Weizmann Institute of Science, IL
introduced by Marc Martí-Renom
14.00 Closing remarks
14.10 Lunch and Departure

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