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06
Apr
2023
Controversial beta cell origin theory challenged by diabetes experts

Dr. Jorge Ferrer challenges the view that adult mice form new beta cells which arise from pancreatic duct cells

RECERCA
06
Apr
2023
tRNA biomarkers for cancer diagnosis and prognosis enabled by new method

The new method can lead to earlier detection of diseases and improved patient outcomes

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30
Mar
2023
Epigenome mapped in detail across human body

International team of CRG, Harvard, Yale, MIT, CSHL and Johns Hopkins publish personalised epigenomes of four individuals in Cell

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07
Mar
2023
Heart toggles between maintenance and energy-boost mode using ribosomes

New mechanism found which can be exploited to prevent or heal damage to the heart 

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13
Feb
2023
Seasonal and circadian genetic variation charted across the human body

Atlas of circadian and circannual variation reveals therapeutic targets which could benefit from different doses depending on time of day and season

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09
Feb
2023
The image shows pancreatic islets in mice, specialised tissues that host beta cells. On the left, a healthy pancreatic islet is shown with its typical morphology with alpha cells in the periphery and beta cells in the core of the islet. On the right, mice with a mutation in Srrm3 that knock out the cells’ ability to regulate microexon inclusion results in islets with altered morphology and cell identity. This and other functional alterations ultimately impacts on the release of insulin. Jonas Juan Mateu
‘Tiny but mighty’ gene fragments are crucial for maintaining blood sugar levels

Microexons constitute new potential therapeutic targets for treating diabetes

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19
Jan
2023
This shows a cross-section of a mouse lung infected with Pseudonomas aeruginosa. The mouse was treated with a version of Mycoplasma pneumoniae that could not produce therapeutic molecules, resulting in severe pneumoniae. This is characterised by massive infiltration of inflammatory cells into the alveolar septa, resulting in loss of air in the alveoli. Credit: Rocco Mazzolini/CRG
‘Living medicine’ created to tackle drug-resistant lung infections

Study showcases synthetic biology's potential in transforming treatment of human disease

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28
Dec
2022
Human diabetes risk influenced by genomic regulation of RNA splicing

RNA splicing regulation influences transcription of genes inked to type-1 and type-1 diabetes risk

RECERCA
28
Nov
2022
Image 1. Mitotic spindles with microtubules (red) attached to chromosomes (blue) during cell division. Cells with normal TTLL11 function (right) have normal rates of microtubule polyglutamylation (green) while cells without TTLL11 (left) are unmodified. Isabelle Vernos
Cell division enzyme earmarked as potential new cancer therapeutic target

The enzyme’s activity was found to be compromised in human cancer cells

RECERCA
27
Oct
2022
Image of a mouse pancreatic islet, regions in the pancreas that contain beta cells which secret insulin. The HASTER regulatory element has been knocked out in this mouse, resulting in changes to beta cell function that cause diabetes. Credit: Miguel A Garriga/
Diabetes-causing gene can be regulated like a rheostat

Studying noncoding RNAs opens new avenues to understand human disease 

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