PRBB-CRG Sessions Oliver Rando

14/03/202512:00MARIE CURIEPRBB-CRG SessionsOliver RandoUniversity of Massachusetts (UMass) Chan Medical School"Environmental control of the mouse sperm epigenome"Host: Eva NovoaAbstract:In addition to delivering a haploid genome complement to the next generation, it is increasingly clear that sperm also carry a payload of so-called epigenetic information that can influence health and disease in offspring. Moreover, a growing literature links paternal environmental exposures to a wide range of phenotypes in the next generation, demonstrating that the sperm epigenome is plastic and can be regulated by environmental conditions. Our lab has a longstanding interest in the mechanistic basis underlying paternal effects in mouse. In this seminar, I will focus on our ongoing efforts to understand how environmental conditions are sensed in the paternal generation, discussing attempts to understand cell non autonomous effects in control of the sperm epigenome.